The recent COVID-19 pandemic has highlighted the importance of fast and accurate virus detection techniques. The traditional nasal swab method and RNA detection via the polymerase chain reaction analysis can lead to many false-positive results and a long diagnostic and wait time. Optical sensing techniques that rely on spectroscopy are very promising for rapid detection of viral and bacterial infection.They also have have the potential to analyze and monitor the efficacy and shelf-life of various vaccines. This can be used to better understand the effects of storage/transportation conditions, temperature, and storage time on the vaccine shelf-life and effectiveness.Virus Detection by Spectral Identification and Analysis

Virus detection and vaccine analysis using optical techniques can be achieved in several ways using the modular IDS photonic tool. The tool offers flexibility in both hardware and software design. It can also use disposable luer lock syringes and dispensers, which makes it ideal for medical applications and bio-research. The modular IDS design enables it to be used for UV/Vis fluorescence, UV/Vis absorbance or reflectance, near-infrared spectroscopy, Fourier transform infrared spectroscopy (FTIR), or Raman spectroscopy. With minor modifications, even surface plasmon resonance-based virus detection is possible. The unique IDS design enables the analysis and direct comparison of various fluids and virus detection without exposing the user or work area to bio contamination. Several samples can be introduced into the dispensers or injected directly into the optical cavity using a Luer syringe. The injection can be done manually or using a syringe pump. The instrument also offers the ability to re-collect and re-use any sample without generating waste. For virus detection or vaccine analysis, the system offers a unique ability to compare reference samples to test samples without even removing the fluids from the syringe.

The following review paper provides an excellent summary on how various optical technologies can be used for virus detection.

Lukose J, Chidangil S, George SD. Optical technologies for the detection of viruses like COVID-19: Progress and prospects. Biosens Bioelectron. 2021 Apr 15;178:113004. doi: 10.1016/j.bios.2021.113004. Epub 2021 Jan 16. PMID: 33497877; PMCID: PMC7832448.